Voltage-Gated Sodium Channel (NaV) Pore-Only Proteins
نویسندگان
چکیده
منابع مشابه
Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins.
Many voltage-gated ion channel (VGIC) superfamily members contain six-transmembrane segments in which the first four form a voltage-sensing domain (VSD) and the last two form the pore domain (PD). Studies of potassium channels from the VGIC superfamily together with identification of voltage-sensor only proteins have suggested that the VSD and the PD can fold independently. Whether such transme...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.1786